Fatigue is a common experience—work pressures, daily chores, and social commitments can leave anyone feeling tired. The NHS highlights typical causes such as poor sleep, an unbalanced diet, insufficient exercise, stress, and significant life events like bereavement. However, persistent exhaustion, especially when combined with other symptoms, may signal a deeper health issue.
“Occasional tiredness is normal and often linked to lifestyle factors,” explains Dennis Ouko, Superintendent Pharmacist at Phlo Clinic. “Usually, rest, exercise, and balanced nutrition help recovery. But if fatigue persists for weeks despite good sleep, or if accompanied by symptoms like general malaise, weakness, or a dull ache in the upper right abdomen, it’s crucial to consult a GP.”
One condition to consider is Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), which the British Liver Trust estimates affects up to one in five adults in the UK. Known as a ‘silent’ disease due to minimal early symptoms, MASLD frequently goes undiagnosed, especially as rates climb alongside obesity.
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Dennis Ouko elaborates: “MASLD occurs when excess fat accumulates in the liver of people who consume little to no alcohol. It’s linked to lifestyle and metabolic issues such as poor diet, obesity, lack of exercise, insulin resistance, type 2 diabetes, and high cholesterol. It’s distinct from Alcohol-related Fatty Liver Disease (AFLD), which is directly caused by excessive alcohol intake. Both can result in liver inflammation, scarring, and potentially liver failure if untreated, but they have different origins and require different management approaches.”
“Being overweight—particularly carrying excess belly fat—is a significant risk factor for MASLD, which is why increased obesity has driven up its prevalence. Other risk groups include individuals with type 2 diabetes, high blood pressure, high cholesterol, or polycystic ovary syndrome. It’s most common in people over 50 and those with unhealthy diets or sedentary lifestyles,” Dennis explains.
Because MASLD often shows few early symptoms and is detected incidentally during other examinations, recognizing warning signs is vital, especially for high-risk individuals. According to the NHS, these may include:
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Persistent fatigue or weakness
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a continual feeling of being unwell or run down
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Mild, dull discomfort in the upper right abdomen
Though less common, symptoms such as unexplained weight loss or loss of appetite can surface in later stages and require urgent medical attention.
Dennis advises: “MASLD progresses through stages, but early detection allows for effective management primarily through lifestyle adjustments. There are currently no dedicated medications, so timely diagnosis is essential. Don’t ignore lasting symptoms or attempt self-diagnosis. Consulting your GP enables proper testing and guidance.”
He adds: “Tracking any unusual symptoms, including their onset and frequency, can assist your doctor in identifying patterns and determining necessary tests or treatment.”
Adopting healthier habits can support liver function and overall wellbeing. This includes eating a balanced diet low in sugar and processed foods and engaging in regular physical activity. If symptoms persist or you have concerns, reach out to your GP without delay.