Tibolone is a hormone replacement therapy (HRT) commonly used to alleviate menopausal symptoms and help prevent osteoporosis. Although it is suitable for many women experiencing menopause, the NHS emphasizes that specific groups should consult their doctor before beginning tibolone treatment.
The NHS identifies 12 key situations where medical advice is crucial. For example, women experiencing unexplained vaginal bleeding, those with porphyria, or individuals with excessive thickening of the womb lining should speak to a healthcare professional prior to using tibolone.
Additionally, anyone currently taking other medications—including herbal remedies, vitamins, or supplements—should seek medical guidance due to possible interactions that could affect the effectiveness or safety of tibolone.
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Official NHS guidance explains, “Tibolone helps restore your hormone levels and is also prescribed to prevent bone thinning after menopause (osteoporosis). It functions similarly to combined HRT containing oestrogen and progestogen, although some studies suggest it may be less effective in raising oestrogen levels.”
Tibolone is only recommended for women who have been post-menopausal for over a year. However, women who have had their ovaries surgically removed or are taking gonadorelin analogues can start tibolone treatment immediately.
The NHS also points out the uncertainty around the safety of combining tibolone with herbal supplements, stating, “These products are not tested with the same rigor as prescription medicines and may influence how other medications work. Therefore, always consult your doctor or pharmacist before taking any new supplements alongside tibolone.”
Tibolone is available by prescription in tablet form, usually taken once daily. It may take up to three months before patients notice an improvement in menopausal symptoms. Common side effects include breast tenderness, vaginal irritation, and abdominal pain, which generally diminish within the first few months of treatment.